Certain benzoquinones, naphthoquinones and derivatives thereof w

Details Certain benzoquinones, naphthoquinones and derivatives thereof w Certain benzoquinones, naphthoquinones and derivatives thereof w

1989-04-25

1991-01-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546284, 546256, C07D40106, C07D40906, A61K 3144

Patent

active

049854470

ABSTRACT:
Quinone derivatives represented by the general formula ##STR1## (wherein, R.sup.1 and R.sup.2, the same or different, refer to hydrogen atom, methyl or methoxymethyl group, or R.sup.1 and R.sup.2 bind together to form --CH.dbd.CH--CH.dbd.CH--; R.sup.3 is hydrogen atom or methyl group; R.sup.4 is nitrogen-containing heterocyclic group which may be substituted; R.sup.5 is hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or carboxyl group which may be esterified or amidated; Z is ##STR2## --CH.dbd.CH--, ##STR3## or ##STR4## (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in [ ]), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more inhibitition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A.sub.2 synthetase, thromboxane A.sub.2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therpeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.

REFERENCES:
patent: 3929880 (1975-12-01), Kirchlechner et al.
patent: 4271083 (1981-06-01), Morimoto et al.
patent: 4393075 (1983-07-01), Terao et al.
patent: 4489096 (1984-12-01), Terao et al.
Hori et al., Chem. Abstracts, vol. 93, No. 25 (1980), p. 810, Abstract No. 238974r.
Furukawa et al., Chem. Abstr. vol. 84, No. 11 (1976), Abstract No. 74280x.
Babichev et al., Chem. Abstr., vol. 70, No. 25, p. 339, Abstract No. 115062j.
Takada et al., Chem. Abstr., vol. 75, No. 9 (1971), p. 432, Abstract No. 63546b.
Cameron et al., Journ. Chem. Soc. (C) 1969, pp. 1245-1251.

Affiliated with

Also associated with

Rating

Certain benzoquinones, naphthoquinones and derivatives thereof w does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain benzoquinones, naphthoquinones and derivatives thereof w, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain benzoquinones, naphthoquinones and derivatives thereof w will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-55562