Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-10-28
1985-06-25
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
549403, 548525, 546196, 544151, 514319, 514422, 514456, A61K 3135, A61K 2700, C07D31130, C07D40510
Patent
active
045253560
ABSTRACT:
Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an ethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R.sub.3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1; X and Y, which must be different, represent a hydrogen atom or methyl group. A represents an amino group having the formula ##STR2## wherein, R.sub.4 and R.sub.5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R.sub.6 represents a lower alkyl group and n represents 2 or 3, are disclosed, as well as pharmaceutical compositions thereof and method of treating therewith.
The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.
REFERENCES:
patent: 2921070 (1960-01-01), Da Re
patent: 3002979 (1961-10-01), Klosa
patent: 3350411 (1967-10-01), Da Re
Nippon, Chem. Abstr., 100, 191648h, (1983).
Itho Yasuo
Kato Hideo
Koshinaka Eiichi
Mitani Kazuya
Ogawa Nobuo
Chan Nicky
Hokuriku Pharmaceutical Co., Ltd.
Hueschen Gordon W.
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