Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1988-06-08
1991-01-15
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Lymphokine
435235, 435236, 435238, 435239, A61K 3912, C12N 700
Patent
active
049852442
ABSTRACT:
A stabilized live attenuated vaccine with improved thermal stability, which comprises a live attenuated plain vaccine consisting of measles, mumps or rubella virus grown in a medium-199 for cell culture, or a combined live attenuated vaccine thereof, containing a stabilizing agent at a final concentration of lactose 2.5-5 W/V %, saccharose 2.5-5 W/V %, D-sorbitol 1.8-2 W/V %, sodium glutamate about 0.1 W/V % and gelatin hydrolyzate, M.W. approx. 35,000, 2-3 W/V %.
REFERENCES:
patent: 4337242 (1982-06-01), Markus et al.
patent: 4338335 (1982-07-01), McAleer et al.
patent: 4500512 (1985-02-01), Barme
"Stability on Storage at Various Temperatures of Live Measles, Mumps and Rubella Virus Vaccines in New Stabilizer", Journal of Biological Standardization, vol. 8, No. 4, 1980, by William McAleer et al., pp. 281-287.
"Behaviour of Five Commercial Measles Vaccines in an Accelerated Stability Test", Journal of Biological Standardization, vol. 10, No. 3, 1982, by G. Colinet et al., pp. 241-247.
"Thermodegradation of Lyophilized Measles Vaccines", Reviews of Infectious Diseases, vol. 5, No. 3, May-Jun., 1983, by F. E. Andre, pp. 532-534.
"Thermostability of Live Freeze-Dried Measles Vaccine After Reconstitution", Proc. Symposium on Stability and Effectiveness of Measles, Poliomyelitis and Pertussis Vaccines, by D. Ikic et al., pp. 103-112.
"The Influence of Storage at 37.degree. C. on the Potency of Frezze-Dried and Reconstituted Live Measles Vaccine", Proc. Symposium on Stability and Effectiveness of Measles, Poliomyelitis and Pertussis Vaccines, by H. Cohen et al., pp. 95-101.
"10th International Immunobiological Symposium", Proceedings, Symposium on Stability and Effectiveness of Measles, Poliomyelitis and Pertussis Vaccines, Organized by Yugoslav Academy of Sciences and Arts and Institute of Immunology, Sep. 1976, pp. 87-94.
Makino Satoshi
Nakagawa Masaharu
Sasaki Keiko
Mohamed Abdel A.
Schain Howard E.
The Kitasato Institute
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