Process for the preparation of benzothiazepin-one derivatives

Details Process for the preparation of benzothiazepin-one derivatives Process for the preparation of benzothiazepin-one derivatives

1990-07-12

1992-01-14

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

562 60, 549549, C07D28110, A61K 3155

Patent

active

050812408

ABSTRACT:
The object of the invention is a process for the preparation of the trans(-) (2R,3S) diastereoisomer of the glycidic esters of general formula: ##STR1## wherein a chlorohydrin of general formula: ##STR2## is reacted with a strong organic base in a suitable solvent and at a temperature between -10.degree. C. and room temperature.
Another object of the invention is intermediate compounds cis(+) (2S,3S) 1,5-benzothiazepin-4-one.

REFERENCES:
Tetrahedron Letters, vol. 27, No. 44, 1986, pp. 5397-5400, Pergamon Journals Ltd, GB; H. Akita et al., "Determination of absolute structure of (-)-oudemansin B".
Journal of the Chemical Society, Perkin Transactions II, No. 10, 1973, pp. 1480-1490.

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