Streptokinase derivatives with high affinity for activated plate

Details Streptokinase derivatives with high affinity for activated plate Streptokinase derivatives with high affinity for activated plate

1997-12-23

2000-07-11

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435216, 435440, 424 9464, 514 2, 536 232, 536 234, A61K 3800

Patent

active

060873329

ABSTRACT:
Streptokinase derivatives having platelet glycoprotein binding domains adjacent to the termini of the streptokinase sequence. These derivatives produce higher local concentrations of plasmin in vivo as compared to unmodified streptokinase. Certain of the derivatives have high affinity for the GPIIB/IIIA receptor and low affinity for the fibronectin and vitronectin receptors. Others have substantially equivalent affinity for all three receptors. The derivatives are useful in treating thromboembolic disorders. The streptokinase derivatives can be made by recombinant techniques or by chemical synthesis or conjugation.

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