Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones

Details Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones

1979-07-26

1980-09-16

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104

Patent

active

042231493

ABSTRACT:
A process for preparing 1,2-dihydro-2-oxo-5-(pyridinyl) nicotinonitriles by reacting .alpha.-(pyridinyl)-.beta.-[di-(lower-alkyl)amino]acrolein with malononitrile in a lower-alkanol. The products are useful as cardiotonic agents and, also, as intermediates for preparing corresponding 3-amino-5-(pyridinyl-2(1H)-pyridinones, in turn, useful as cardiotonic agents.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
Nantkanamirski et al., "Polish-J. Pharmacol Pharmacy" vol. 30, No. 5, pp. 707-712 (1978).

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