Process for preparing cephalosporin antibiotics

Details Process for preparing cephalosporin antibiotics Process for preparing cephalosporin antibiotics

1978-11-28

1980-09-16

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D50104

Patent

active

042231345

ABSTRACT:
The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclicthiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

REFERENCES:
patent: 3694437 (1972-09-01), Jackson
patent: 4035361 (1977-07-01), Wheeler
patent: 4064122 (1977-12-01), Ishimaru
patent: 4098796 (1978-07-01), Guddal
patent: 4112088 (1978-09-01), Berges

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