Lipopolyamines, their preparation and their use

Details Lipopolyamines, their preparation and their use Lipopolyamines, their preparation and their use

1995-06-07

1997-04-01

Carr, Deborah D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 35, 554 51, 554 68, 554 69, 554 78, 554 79, 554 80, 554 82, 558166, 558169, 558170, 558177, 558178, 558179, 558180, 558182, 564 15, 564192, 564193, 564197, 568579, 568583, 568589, 568671, 568672, C07C23300, C07C23500

Patent

active

056167458

ABSTRACT:
New lipopolyamines of general formula (I), their salts, their preparation and their use. ##STR1## n=1 to 5 and m=2 to 6 R represents a radical ##STR2## (R.sub.1 and R.sub.2 : aliphatic radical containing 12 to 22 carbon atoms; R: hydrogen atom or alkyl radical optionally substituted with phenyl), or a radical ##STR3## (X=CH.sub.2, CO; R.sub.3 and R.sub.4 aliphatic radical containing 11 to 21 carbon atoms), their preparation and their use.
The lipopolyamines of general formula (I) are especially useful as vectors for the transfection of eukaryotic cells.

REFERENCES:
patent: 3869273 (1975-03-01), Noveroske
patent: 4324683 (1982-04-01), Lim et al.
patent: 5171678 (1992-12-01), Behr et al.
Yamada et al., Chemical Abstracts, 95:145264 1981.
Patel et al. Chemical Abstracts, 106:68140 1987.
Gaymans et al., Chemical Abstracts, 102:149886 1984.
Ueda et al., Chemical Abstracts, 108:97951 1987.
Boeckman, Jr. et al Journal of Organic Chemistry, vol. 51, #26, pp. 5486-5489, 1986.
Tetrahedron Letters, vol. 27, No. 48, 1986, pp. 5861-5864, Pergamon Journals Ltd., J. P. Behr, "DNA Strongly Binds to Micelles and Visicles Containing Lipopolyamines or Lipointercalants". Copy of EPO Search Report dated Jul. 3, 1990.
Proceedings of National Academy of Sciences of USA, vol. 86, No. 18 Sep. 1989, pp. 6982-6986 J.P. Behr, et al. "Efficient Gene Transfer into Mammalian Primary Endocrine Cells with Lipopolyamine-Coated DNA".

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