Hydrophobic pseudo-peptides

Details Hydrophobic pseudo-peptides Hydrophobic pseudo-peptides

1988-07-13

1991-09-10

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514 18, A61K 3702, C07K 706

Patent

active

050473999

ABSTRACT:
Novel hydrophobic psuedo-peptides of formula I ##STR1## wherein R.sub.1 is lower alkyl or -CH.sub.2 CONR.sub.6 R.sub.7 ; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently lower alkyl, cycloalkyl lower alkyl, aryl lower alkyl, heteroaryl lower alkyl, aryl lower alkoxy, substituted aryl lower alkyl, wherein the aryl portion is substituted with 1-3 substituents independently selected from lowr alkyl, hydroxyl, lower alkoxy and halogeno, substituted heteroaryl lower alkyl wherein the substituents on the heteroaryl portion are as defined for aryl lower alkyl, substituted cycloalkyl lower alkyl, wherein the substituents on the cycloalkyl portion are as defined for aryl lower alkyl, and substituted aryl lower alkoxy wherein the substituents are as defined for aryl lower alkyl;

REFERENCES:
patent: 4609641 (1986-09-01), Evan et al.
patent: 4629724 (1986-12-01), Ryono et al.
patent: 4645759 (1987-02-01), Luly et al.
patent: 4725584 (1988-02-01), Luly et al.
patent: 4766109 (1988-08-01), Czarniecki et al.
Gaeta et al., "Small Peptide Inhibitors of Smooth Muscle Myosin Light Chain Kinase", Journal of Medicinal Chemistry, 33, 964, 1990.

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