Topically administrable zinc phthalocyanine compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424450, 514422, 514863, A61K 3140

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active

056166028

ABSTRACT:
A topically administrable pharmaceutical composition comprising (A) zinc phthalocyanine complex, (B) as carrier for the complex, (i) a N-alkylpyrrolidone together with a pharmaceutically acceptable co-solvent for the complex, (ii) dimethyl sulphoxide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, (iii) a liposome, or (iv) a N,N-dialkylbenzamide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, and (C) a gelling agent.

REFERENCES:
patent: 4440777 (1984-04-01), Zupan
patent: 4753958 (1988-06-01), Weinstein et al.
patent: 5270053 (1993-12-01), Schneider et al.
Chem Abstr. vol. 119; No. 21; 220657k; Margaron et al; Int. Cong. Ser.-Excerpta Med (1992), 1101 (Photodynamic Therapy and Biomedical Layers pp. 850-854).
Margaron et al; Int. Cong. Ser.-Excerpta Med (1992); Photodynamic Therapy and Biomedical Lasers pp. 850-854; "Photodynamic Therapy with topical phthalocyanine formulations on Intradermally Transplanted . . . ".
Spikes, Photochem. Photobiol. 43, 691-699 (1986) Phthalocyanines as Photosensitizers in Biological Systems and for the Photodynamic Therapy of Tumors.

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