Chelating agent, complex compound of said chelating agent and me

Details Chelating agent, complex compound of said chelating agent and me Chelating agent, complex compound of said chelating agent and me

1995-04-19

1996-11-19

Nazario-Gonzales, Porfirio

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 514492, 514502, 534 16, 556 1, 556148, 562565, 562566, 424 942, 424 95, A61K 4900, A61K 3132, A61K 31295

Patent

active

055759866

ABSTRACT:
A compound of the following formula ##STR1## wherein m is an integer of 1 to 3, R.sub.1 and R.sub.2 are the same or different and each is hydrogen atom or lower alkyl, and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are the same or different and each is hydroxy or a group of the formula ##STR2## (wherein n is 0 or 1, X is --NH-- or --O--, Y is alkylene, A is hydrogen atom, lower alkyl, lower alkoxy, halogen atom or trifluoromethyl, and B is alkyl or alkenyl), with the proviso that two or three of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydroxyl groups and that when two of them are hydroxyl groups, the cases where R.sub.3 and R.sub.5 are hydroxy, and R.sub.4 and R.sub.6 are hydroxy are excluded; a complex compound comprising said compound and a metallic atom; and a diagnostic agent containing said complex compound. The above compound is useful as a chelating agent and the complex compound comprising said compound and a metallic atom exhibits superior characteristics as a contrast medium for image diagnosis.

REFERENCES:
patent: 5138039 (1992-08-01), Seri et al.

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