Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivativ

Details Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivativ Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivativ

1989-03-02

1991-09-10

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

560 37, 560 42, 564153, 564156, A61K 4904

Patent

active

050472283

ABSTRACT:
Nonionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --COOR.sub.3, --CH.sub.2 NHR.sub.7 or --CH.sub.2 OH; Y is --1R.sub.1 R.sub.2 or --OR.sub.3 ; and Z is --NR.sub.1 R.sub.2, --NHR.sub.7 or --OR.sub.3 ; and wherein R.sub.1 R.sub.2 and R.sub.3 in X, Y or Z, and R.sub.7 in X and Z, are identical or different, R.sub.1 and R.sub.2, and each is hydrogen, C.sub.1-6 -alkyl or C.sub.2-8 - alkyl substituted by 1-5 OH groups and/or by a C.sub.1-3 -alkoxy group; R.sub.3 is C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-2 OH groups and/or by a C.sub.1-3 -alkoxy group; and R.sub.7 is an acyl group of a C.sub.2-5 OH group and/or by a C.sub.1-3 -alkoxy group are highly advantageous X-ray contrast agents.

REFERENCES:
patent: 4001323 (1977-01-01), Felder
patent: 4021481 (1977-05-01), Almen
patent: 4062934 (1977-12-01), Tilley
patent: 4250113 (1981-02-01), Nordal
patent: 4269819 (1981-05-01), Gries

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