DNA sequence which binds transcriptional regulatory proteins act

Details DNA sequence which binds transcriptional regulatory proteins act DNA sequence which binds transcriptional regulatory proteins act

1995-02-24

1997-04-01

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 43525411, 4353201, 435357, 536 241, C07H 2104

Patent

active

056164890

ABSTRACT:
An oligonucleotide comprising the DNA sequence TTTCCNGGAAA (SEQ ID NO:1) in single stranded or double stranded form, or a derivative thereof, binds to transcriptional regulatory proteins induced by cytokines, growth factors or hormones. Such oligonucleotides are useful in detecting, identifying or purifying transcriptional regulatory proteins. Recombinant DNA constructs comprising the oligonucleotide sequence operably linked to a promoter and a reporter DNA sequence and cells transfected therewith are also disclosed. Also disclosed are DNA-binding proteins other than p91 which are inducible in a cell by a cytokine, growth factor or hormone, and which, when tyrosine phosphorylated, bind to the above oligonucleotide DNA sequence.

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