Non-steroid topical agent for alleviating inflammation in mammal

Details Non-steroid topical agent for alleviating inflammation in mammal Non-steroid topical agent for alleviating inflammation in mammal

1976-01-27

1977-05-24

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3123

Patent

active

040256456

ABSTRACT:
The present invention is a method of treating mammals for alleviating inflammation by utilization of a non-steroid topical agent. The agent is ethyl linoleate [ethyl-cis,cis(9,12)-octadecadienoate] which may be combined in a preferred formulation with one or more antioxidants such as .alpha.-tocopherol, d,l-histidine, and tertiary butyl hydroquinone; a stabilizer such as Tween-80; and inert esters such as ethyl oleate, ethyl palmitate, and ethyl stearate. The agent is applied in a therapeutic dosage range of 0.2-0.8 mg/cm.sup.2 of body surface both internal and external, with a preferred dosage of 0.5 mg/cm.sup.2. This topical remedy for inflammation for internal and external body surfaces is utilized principally in a single dose but may be utilized in multiple doses are required due to low toxicity (60:1). Among the conditions with inflammatory responses amenable to treatment are ultraviolet ratiation, solar radiation, non-infectious conjunctivitis, hemorrhoids (acute), abrasions, ingrown finger or toenail (granulation), skin graft donor sites, vaginitis, poison ivy, psoriasis, herpes simplex (cold sores, aphthous ulcers), pruritis ani/cruri, chemical inflammation, and insect stings/bites.

REFERENCES:
patent: 3676472 (1972-07-01), Zilliker
patent: 3920848 (1975-11-01), Jelenko

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