Non-aqueous colonic purgative formulations

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Phosphorus or phosphorus compound

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514892, A61K 3342

Patent

active

056163460

ABSTRACT:
Orally administered colonic purgative formulations and methods of its use for effecting partial or complete purgation of the colon in mammals, the formulations consisting of non-aqueous admixtures of monobasic, dibasic and tribasic sodium phosphates administered in tablet or capsule form in concentrations of from 0.01 to 0.85 grams per kilogram body weight. Preferred embodiments include the addition of binders, dispersants and buffers which do not adversely affect osmolality or effectiveness of the purgative formulations.

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A Randomized Prospective Trial Comparing Oral Sodium Phosphate with Standard Polyethylene Glycol-Based Lavage Solution (Golytely) in the Preparation of Patients for Colonoscopy; Vanner, M.D., et. al.; The American Journal of Gastroenterology; vol. 85, No. 4, p. 422; 1990.
Development of a Lavage Solution Associated with Minimal Water and Electrolyte Absorption or Secretion; Davis, et. al.; Gastroenterology 76:991-995, 1980.
Physicians' Desk Reference; pp. 699-700;992-993; & 1826-1827;1992.
Martindale, The Extra Pharmacopoeia, 28.sup.th edition (1982) pp. 641-642.
Physician's Desk Reference, 1995 (ed) pp. 608-609.

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