Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-14
1993-04-06
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514563, 514564, 514565, 558405, 549551, 562444, 562448, 562564, 562567, 562568, 562576, 562571, A61K 31335, C07C25519, C07C22924
Patent
active
052004260
ABSTRACT:
The present disclosure relates to inhibitors of neutral endopeptidase (NEP) which are proposed as novel agents for the treatment of CALLA+ positive cancers as well as other conditions such as hypertension.
REFERENCES:
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Letarie et al., "Common Acute Lymphocytic Leukemia Antigen is Identical to Neutral Endopeptidase", J. Exp. Med., 1988, vol. 168, pp. 1247-1253.
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Maldonado, et al., "Differences in Physical Dependence Induced by Selective .mu. or .delta. Opioid Agonists and by Endogenous Enkephalins Protected by Endogenous Enkephalins Protected by Peptidase Inhibitors", Brain Research, 1990, vol. 520, pp. 247-254.
Al-Rodhan et al., "The Antinociceptive Effects of SCH-32615, a Neutral Endopeptidase (Enkephalinase) Inhibitor, Microinjected into the Periagueductal, Ventral Medulla and Amygdala", Brain Research, 1990, vol. 520, pp. 123-130.
Shipp et al., "Common Acute Lymphoblastic Leukemia Antigen (CALLA) is Active Neutral Endopeptidase 24.11 (Enkephalinase): Direct Evidence by cDNA Transfection Analysis", Proc. Nat. Acad. Sci., 1989, vol. 86, pp. 297-301.
Bateman, Jr. et al., "N-Bromoacetyl-D-Leucylglycine", Journal of Biological Chemistry, 1990, vol. 265, pp. 8365-8368.
Bateman, Jr. et al., "Evidence for an Essential Histidine in Neutral Endopeptidase 24.11", Biochemistry, 1987, vol. 26, pp. 4237-4242.
Bateman, Jr. R. C.
Hersh Louis B.
Board of Regents The University of Texas
Owens A. A.
Rotman Alan L.
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