Substituted tetrazoles and derivatives thereof acting at muscari

Details Substituted tetrazoles and derivatives thereof acting at muscari Substituted tetrazoles and derivatives thereof acting at muscari

1990-05-21

1993-04-06

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546187, 546188, C07D21136, C07D40106

Patent

active

052004198

ABSTRACT:
Substituted tetrazoles and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting muscarinic agents and are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.

REFERENCES:
patent: 2470084 (1949-05-01), Harvill et al.
patent: 3767667 (1973-10-01), Kamiya et al.
patent: 4372953 (1983-02-01), Uchida et al.
patent: 4563455 (1986-01-01), Ueda et al.
patent: 4791210 (1988-12-01), Bison et al.
patent: 4900839 (1990-02-01), Campbell et al.
Chemische Berichte, 103, pp. 2821-2827 (1970) Reimlinzer, H., et al.
Liebigs Annalen der Chemie, 725, pp. 29-36 (1969) Zbiral, E., & Stroh, J.

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