Pharmaceutical sustained release matrix and process

Details Pharmaceutical sustained release matrix and process Pharmaceutical sustained release matrix and process

1990-10-22

1993-04-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424472, 424469, 424470, A61R 972

Patent

active

052001938

ABSTRACT:
A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.

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"Hardness Increase etc" Chowan et al. Journ. of Pharmaceutical Science, vol. 67, No. 11, pp. 1385-1389, Oct., 1978.

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