Synthetic vaccine and process for producing same

Details Synthetic vaccine and process for producing same Synthetic vaccine and process for producing same

1981-12-29

1984-10-02

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424177, 260112R, 2601125R, A61K 3900, A61K 3702, C07C10352, C07G 700

Patent

active

044747578

ABSTRACT:
There is provided a synthetic vaccine against influenza virus infections consisting of a synthetic peptide corresponding to a relevant antigenic fragment of the virus, which fragment is attached to a suitable carrier, such as a macromolecule. Effective vaccinations against a plurality of strains can be obtained when the antigenic fragment is one common to such strains. Such synthetic vaccines are produced by synthesizing peptides corresponding to such relevant antigenic fragments and coupling same to a suitable carrier, such as a macromolecule. There is also provided a process for the vaccination of mammals against influenza which comprises applying to said mammals an effective quantity of a vaccine according to the invention.

REFERENCES:
Sela, M. et al., "Antiviral Antibodies Obtained with Aqueous Solution of a Synthetic Antigen", New Developments with Human & Vet. Vaccines pp. 315-323 (1980).
Arnon, R. "Synthetic Vaccines--A Dream or Reality" Eur. J. Biochem. 31, 534-540 (1972).
Arnon, R. et al., "Antiviral Response Elicited by a Completely Synthetic Antigen with Built-in Adjuvanticity" Proc. Natl. Sci. U.S.A. vol. 77, No. 11, pp. 6769-6772 (1980).
Muller, G. M. et al., "Anti-Influenza Response Achieved by Immunization with a Synthetic Conjugate", Proc. Natl. Acad. Sci. USA, vol. 79, pp. 569-573 (1982).
Laver, W. G. et al., "Amino Acid Sequence Changes in the Haemagglutinin of A/Hong Kong (H3N2) Influenza Virus During Period 1968-1977" McMillan Journals Ltd. (1980) pp. 454-457.
Jackson, D. C. et al., "Immunogenicity of Fragments Isolated from the Hemagglutinin of A/Memphis/72", The Journal of Immunology, vol. 123, No. 6, pp. 2610-2617 (1979).
Lerner, R. A., "Synthetic Vaccines" Scientific American, pp. 66-74 (1983).
Walter et al., Proc. Natl. Acad. Sci. USA, vol. 77, No. 9, pp. 5197-5200, Sep. 1980.
Sutcliffe et al., Nature, vol. 287, pp. 801-805, Oct. 30, 1980.
Arnon et al., Proc. Natl. Acad. Sci. USA, vol. 68 No. 7, pp. 1450-1455 (1971).
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