Thiophene derivatives and their pharmaceutical compositions and

Details Thiophene derivatives and their pharmaceutical compositions and Thiophene derivatives and their pharmaceutical compositions and

1980-10-23

1983-05-10

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

549 59, 549 60, 549 74, 549 75, 549 76, 42424851, 424249, 424251, 424263, 424267, 424269, 424270, 424272, 424274, 424275, 544 60, 544212, 544146, 544333, 546212, 546284, 548266, 548255, 548161, 548212, 548233, 548245, 548527, C07D41706, A61K 3138

Patent

active

043829295

ABSTRACT:
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which R.sub.4 represents hydrogen, C.sub.1-10 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heteroaralkyl, trifluoroalkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino or cycloalkyl, and R.sub.5 represents hydrogen or a C.sub.1-4 alkyl group or R.sub.4 and R.sub.5 may, together with the nitrogen atom to which they are attached, form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom selected from oxygen and sulphur;

REFERENCES:
patent: 4239769 (1980-12-01), Price et al.

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