Process for preparing heteroaromatic methyl)-2,2'-bi-1H-imidazol

Details Process for preparing heteroaromatic methyl)-2,2'-bi-1H-imidazol Process for preparing heteroaromatic methyl)-2,2'-bi-1H-imidazol

1989-03-27

1990-05-29

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548335, 548336, 548342, 548346, C07D23354, C07D27720

Patent

active

049297449

ABSTRACT:
This invention relates to a process for preparing (aryl) or heteroaromatic methyl)-2,2'-1H-biimidazoles. Reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.

REFERENCES:
P. Melloni, et al., J. Med. Chem., 15, No. 19,926 (1972).
Katritzky, Comprehensive Heterocyclic Chemistry, vol. 5, Part 4A, 386-389 (1986).

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