Method for the synthesis of huperzine A and analogs thereof and

Details Method for the synthesis of huperzine A and analogs thereof and Method for the synthesis of huperzine A and analogs thereof and

1989-02-21

1990-05-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 93, 546134, 546249, C07D22122

Patent

active

049297317

ABSTRACT:
The present invention relates to a method for the synthesis of certain bridged fused ring pyridines. Such bridged fused ring pyridines can be converted to huperzine A and analogs of huperzine A. The present invention also covers such bridged fused ring pyridines, compounds utilized for the preparation of the bridged fused ring pyridines and analogs of huperzine A.

REFERENCES:
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Chen II CA 108:143270x of Yauxue Xuebao 1987, 22(11), 801-6.
Yu, Can J. of Chem, 64, 837-839 (1986) Structure of Huperzine.
Gravel, Can. J. of Chem, 62, 2945-2947 (1984) Total Regiospecific Synthesis of Selagine.
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C. M. Yu et al., Canadian Journal of Chemistry 64, 837-839 (1986), The Structures of Huperzine A and B, Two New Alkaloids Exhibiting Marked Anticholinesterase Activity.
D. Gravel et al., Canadian Journal of Chemistry, 62, 2945-2947 (1984), Total Regiospecific Synthesis of Selagine Tricylcic Ring System.
W. Ye et al., Acta Pharmacologica Sinica, 9, 1930196 (1988), Pharmacokinetics of Huperzine A in Rats and Mice.
C. Shi-Ming et al., Acta Pharmaceutica Sinica, 22, 801-806 (1987), The Effects of Fordine on Learning and Memory in Rats.
A. Kende et al., Heterocycles, 21, 91-106, New Tactics in Heterocyclic Synthesis.

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