Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-08-20
1994-07-19
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 703, C07K 302, C07K 328, C12P 2102, A61K 3743
Patent
active
053310918
ABSTRACT:
A novel melanin formation-inhibitory protein, which has a molecular weight of 90,000.+-.20,000 and a pI of 5.5.+-.0.5, exerts a tyrosinase formation-inhibitory activity in pigment cells but does not substantially inhibit the inherent tyrosinase activity. Thus, the protein is advantageously used as a pharmaceutical and as a cosmetic in the prevention and/or treatment for local chromatosises such as chloasma, ephelis and sunburn, as well as for systemic chromatosises such as addisonism.
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Fukuda Shigeharu
Kurimoto Masashi
Suemoto Yasuo
Gromet Nancy J.
Kabushiki Kaisha Hayashibara Seitbutsu Kagaku Kenkyujo
Russel Jeffrey E.
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