Spirocyclopropyl fluorenes as melatonergic agents

Details Spirocyclopropyl fluorenes as melatonergic agents Spirocyclopropyl fluorenes as melatonergic agents

1998-07-31

2000-02-22

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514530, 514534, 514538, 514595, 514624, 514625, 514627, 514629, 560 27, 560 28, 564 57, 564 60, 564189, 564190, 564204, 564219, 564220, 564222, A61K 3116, C07C23305

Patent

active

06028112&

ABSTRACT:
There is provided novel spirocyclopropyl fluorene derivatives having the general Formula I ##STR1## wherein R, R.sup.1 and X are as defined herein which are useful as melatonergic agents.

REFERENCES:
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patent: 5596019 (1997-02-01), Mattson et al.
Arendt, J., et al., "Alleviation of Jet Lag by Melatonin: Preliminary Results of Controlled Double Blind Trial", Br. Med. J., 292, p. 1170 (May 1986).
Cassone, V. M., et al., "Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin", J. Biol. Rhythms, 1, (3), pp. 219-229 (1986).
Copinga, S., et al., "2-Amino-8-methoxytetralins: A Series of Nonindolic Melatonin-like-Agents", J. Med. Chem., 36, pp. 2891-2898 (1993).
Reppert, S. M., et al., "Cloning and Characterization of a Mammalian Melatonin Receptor That Mediates Reproductive and Circadian Responses", Neuron, 13, pp. 1177-1185(Nov., 1994).
Reppert, S. M., et al., "Molecular Characterization of a Second Melatonin Receptor Expressed in Human Retina and Brain: The Mel.sub.1b Melatonin Receptor ", Proc. Natl. Acad. Sci. USA, 92, pp. 8734-8738 (Sep. 1995).

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