Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-13
2000-02-22
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514456, 514912, A67K 3135, A67K 31389
Patent
active
060280999
ABSTRACT:
The present invention is directed to a method for the prophylactic and therapeutic treatment of choroidal neovascularization. The method involves the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the choroid for neovascularization prophylactically or therapeutically. The inhibitor of the protein tyrosine kinase pathway is preferably genistein or an analogue or prodrug thereof or a pharmaceutically acceptable salt of any of the foregoing.
REFERENCES:
patent: 5637703 (1997-06-01), Mazurek et al.
Barnes, "Effect of Genistein on In Vitro and In Vivo Models of Cancer," J. Nutr. 125: 777S-783S (1995).
Barnes et al., "Biochemical Targets of the Isoflavone Genistein in Tumor Cell Lines," PSEBM 208: 103-108 (1995).
Burke, Jr. "Protein-Tyrosine Kinase Inhibitors," Drugs of the Future 17(2): 119-131 (1992).
Coward et al., "Genistein, Daidzein, and Their .beta.-Blycoside Conjugates: Antitumor Isoflavones in Soybean Foods from American and Asian Diets," J. Agric. Food Chem. 41: 1961-1967 (1993).
Cunningham et al. "Synthesis and Biological Evalutation of a Series of Flavones Designed as Inhibitors of Protein Tyrosine Kinases," Anti-Cancer Drug Design 7: 365-384 (1992).
Filipeanu et al., "Multiple Effects of Tyrosine Kinase Inhibitors on Vascular Smooth Muscle Contraction," European Journal of Pharmacology 281(1): 29-35 (1995) (Abstract).
Fotsis et al., "Genistein, A Dietary Ingested Isoflavonoid Inhibits Cell-Proliferation and In-Vitro Angiogenesis," Journal of Nutrition 125(3): 790-797 (1995) (Abstract).
Fotsis et al., "Genistein, a Dietary-Derived Inhibitor of In Vitro Angiogensis," PNAS USA 90: 2690-2694 (1993).
Hayashi et al., "Activation of Protein Tyrosine Phosphorylation After Retinal Branch Vein Occlusion in Cats," Investigative Ophthalmology & Visual Science 38(2): 372-380 (1997).
Hayashi et al., "Increase of Protein Tyrosine Phosphorylation in Rat Retina After Ischemia-Reperfusion Injury," Investigative Ophthalmology & Visual Science 7(11): 2146-2156 (1996).
Hayashi et al., "Genistein, a Protein Tyrosine Kinase Inhibitor, Ameliorates Retinal Degeneration After Ischemia-Reperfusion Injury in Rat," Investigative Ophthalmology & Visual Science 38(6): 1193-1202 (1997).
Hayashi et al., "Role of Protein Tyrosine Phosphorylation in Rat Corneal Neovascualrization," Graefe's Arch. Clin. Exp. Ophthalmol. 235: 460-467 (1997).
Hayashi et al., "Genistein, A Protein Tyrosine Kinase Inhibitor, Ameliorates Retinal Degeneration After Ischemia-Reperfusion Injury in Rat," Investigative Ophthalmology and Visual Science 38(4): 489-B400 (1997) (Abstract).
Herman et al., "Soybean Phytoestrogen Intake and Cancer Risk," J. Nutr. 125: 757S-770S (1995).
Kennedy, "The Evidence of Soybean Products as Cancer Preventive Agents," J. Nutr. 125: 733S-742S (1995).
Kindy, "Inhibition of Tyrosine Phosphorylation Prevents Delayed Neuronal Death Following Cerebral Ischemia," Journal of Cerebral Blood Flow and Metabolism 13: 372-377 (1993).
Koroma et al., "Changes Associated With Tyrosine Phosphorylating During Short-Term Hypoxia in Retinal Microvascular Endothelial Cells In Vitro," Journal of Cellular Biochemistry 59: 123-132 (1995).
Koroma et al., "Phosphotyrosine Inhibition and Control of Vascular Endothelial Cell Proliferation by Genistein," Biochemical Pharmacology 48(4): 809-818 (1994).
Lamartiniere et al., "Neonatal Genistein Chemoprevents Mammary Cancer,"PSEBM 208: 120-123 (1995).
Levitzki et al., "Tyrosine Kinase Inhibition: An Approach to Drug Development," Science 267: 1782-1790 (1995).
Lu et al., "Effects of Soya Consumption for One Month on Steroid Hormones in Premenopausal Women: Implications for Breast Cancer Risk Reduction," Cancer Epidemiology, Biomarkers & Prevention 5: 63-70 (1996).
Moritoki et al., "Possible Involvement of Tyrosine Kinase in the LPS-Promoted Initiation of L-arginine-Induced Relaxation of Rat Aorta Mediated by Induction of N.sub.o Synthase," Life Science 57(11): PL125-130 (1995) (Abstract).
Ohira et al., "Retinal Ischemia and Cell Proliferation in the Rat: The Role of Soluble Mitogens," Graefe's Arch Clin. Exp. Ophthalmol. 228: 195-199 (1990).
Raines et al., "Biology of Atherosclerotic Plaque Formation: Possible Role of Growth Factors in Lesion Development and the Potential Impact of Soy," Journal of Nutrition 125(3 Suppl.): 624S-630S (1995) (Abstract).
Steele et al., "Cancer Chemoprevention Agent Development Strategies for Genistein," J. Nutr. 125: 713S-716S (1995).
Steusloff et al., "Modulation of Ca2+ Sensitivity in Smooth Muscle by Genistein and Protein Tyrosine Phosphorylation," Archives of Biochemistry & Biophysics 320(2): 236-242 (1995) (Abstract).
Wilcox et al., "Thrombic Mechanisms in Atheroscelorsis: Potential Impact of Soy Proteins," Journal of Nutrition 125(3): 631S-638S (1995) (Abstract).
Xiong et al., "Modulation of Ca(2+)-activated K+ Channel Activity by Tyrosine Kinase Inhibitors in Vascular Smooth Muscle Cell," European Journal of Pharmacology 290(2): 117-123 (1995) (Abstract).
Fay Zohreh
John Hopkins University School of Medicine
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