Substituted 2-amino-4-(hydroxyamino)-pyrimidines

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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Details

2602564C, 2602565R, 424251, C07D23942

Patent

active

039474410

ABSTRACT:
Cpmpounds of the class of 5-substituted and 5,6-disubstituted 2-amino-4-(hydroxyamino) and 2,4-bis-(hydroxyamino)pyrimidines and their pharmaceutically acceptable acid addition salts possess valuable biological properties, in particular antibacterial and antimalarial activity and potentiate the action of antibacterial sulphanilamide derivatives. Specific embodiments are 2-amino-4-(hydroxyamino)-5-(3,4,5-trimethoxybenzyl)-pyrimidine, and 2-amino-4-(hydroxyamino)-5-(p-chlorophenyl)-6-ethyl pyrimidine and its hydrochloride.

REFERENCES:
patent: 3513185 (1970-05-01), Cresswell et al.

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