Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm

Details Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm

1985-11-18

1990-03-13

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568313, 568316, C07C 49248

Patent

active

049084810

ABSTRACT:
A simple process for preparing 1-(4-hydroxy-phenyl)-butan-3-one, a sought-after natural aromatic, in a pure form and in good yield from easily accessible starting materials, wherein a 4-tert-alkoxy-benzaldehyde is condensed, under alkaline conditions, to give a novel 1-(4-tert.-alkoxy-phenyl)-but-1-en-3-one, the latter is hydrogenated, during or after this condensation, to give a novel 1-(4-tert.-alkoxy-phenyl)-butan-3-one, and isobutene or 2-methyl-but-1(2)-ene is eliminated from this compound in the presence of a catalytic amount of an acid. The novel intermediates have the general formula ##STR1## where R is H or CH.sub.3 and the broken line may or may not be an additional carbon-carbon bond.

REFERENCES:
patent: 3098874 (1963-07-01), Porsch et al.
patent: 3420853 (1969-01-01), Moed et al.
patent: 3928421 (1975-12-01), Kyogoku et al.
patent: 3997608 (1976-12-01), Suh
patent: 4062978 (1977-12-01), Cole et al.
patent: 4218468 (1980-08-01), Paul
patent: 4271319 (1981-06-01), Tang et al.
patent: 4290974 (1981-09-01), Bouillon et al.
mcOmie, "Protective Groups in Organic Chem.", pp. 157-167 (1973), Blenun Press.
Papa et al., I.A.C.S., Vol. 70, pp. 3358-3360 (1948).
House, Modern Synthetic Reactions, pp. 632-642 (1972).

Affiliated with

Also associated with

Rating

Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 1-(4-hydroxy-phenyl)-butan-3-one and novel interm will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-52027