Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-07-23
1994-07-19
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514309, 546139, 546144, A61K 3147, C07D21512
Patent
active
053309910
ABSTRACT:
Tetrahydroisoquinoline derivatives of the following formula [I] and acid addition salts thereof, and ##STR1## (wherein in all of these formulae, R.sup.1 represents C.sub.1 -C.sub.5 straight or branched alkyl, C.sub.2 -C.sub.5 straight or branched alkenyl or C.sub.2 -C.sub.5 straight or branched alkynyl; R.sup.2 represents hydrogen atom, C.sub.1 -C.sub.10 straight or branched alkyl, C.sub.2 -C.sub.10 straight or branched alkenyl, C.sub.2 -C.sub.10 straight or branched alkynyl, C.sub.1 -C.sub.10 straight or branched alkoxy, C.sub.2 -C.sub.10 straight or branched alkenyloxy, C.sub.2 -C.sub.10 straight or branched alkynyloxy, or C.sub.1 -C.sub.10 straight or branched halogenated alkyl; R.sup.3, R.sup.4 R.sup.5 and R.sup.6, the same or different represent hydrogen atom, C.sub.1 -C.sub.10 straight or branched alkyl, C.sub.2 -C.sub.10 straight or branched alkenyl, C.sub.2 -C.sub.10 straight or branched alkynyl, C.sub.1 -C.sub.10 straight or branched alkoxy, C.sub.2 -C.sub.10 straight or branched alkenyloxy, C.sub.2 -C.sub.10 straight or branched alkynyloxy or halogen atom, with the proviso that R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are not hydrogen atoms simultaneously).
REFERENCES:
Margni et al, Journal of the Chemical Society (C), pp. 2578-2580, 1970.
Ibanez et al. Journal of Heterocyclic Chemistry, vol. 26, No. 4, pp. 907-911, Jul. Aug. 1989.
J. Org. Chem., vol. 43, No. 2, 1978 Cushman et al "Total Synthesis of Nitidine Chloride" pp. 286-288.
J. Am. Chem. Soc. 1983, 105, 2873-2879 Cushman et al "Total Synthesis of . . . Oxocorynoline".
Prabhaker et al, Journal of the Chemical Society, Perkin Transactions 1 (1981), pp. 1273-1277, "Total Synthesis of the Alkaloids (.+-.)-Alpinigenine and (.+-.)cis-Alpinigenine".
Haimova et al., Tetrahedron, vol. 33, No. 3, pp. 331-336 (1977) "A Highly Stereoselective Synthesis of 3,4-Dihydro-1(2H)-Isoquinolinones and 8-Oxoberbines from Homophthalic Anhydrides and Azomethines".
Ide Teruhiko
Tokunaga Takumi
Tsuzuki Kenji
Watanabe Hiroyuki
Davis Zinna N.
Ivy C. Warren
Tosoh Corporation
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