Nitrogen-sulfur ligands as opiate receptor drug mimics

Details Nitrogen-sulfur ligands as opiate receptor drug mimics Nitrogen-sulfur ligands as opiate receptor drug mimics

1991-12-06

1994-07-19

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

534 10, 534 14, 546331, 546334, 546336, 546337, A61K 4902, A61K 4300, C07D21374, C07D21383

Patent

active

053307372

ABSTRACT:
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, such as Tc, Re, or Ga, and are useful as general imaging agents for diagnostic purposes. The ligands have the general formulae (I) and (II): ##STR1## wherein for formula I, R.sup.1 -R.sup.4, R.sup.6, R.sup.7 and R.sup.9 -R.sup.14 can each be one of H, alkyl, aryl, hydroxyalkyl, alkoxycarbonyl, etc.; R.sup.5 and R.sup.8 are suitable sulfur protecting groups; m and n are 1-3; B can be one of C(O)CHR.sup.6 CHR.sup.7 SR.sup.8, CHR.sup.9 CHR.sup.10 C(O)NHR.sup.11, or C(O)CHR.sup.12 CHR.sup.13 NHR.sup.14 ;

REFERENCES:
patent: 2751389 (1956-06-01), Bersworth
patent: 4963682 (1990-10-01), Bodor
patent: 5071636 (1991-12-01), Yamauchi et al.
patent: 5202451 (1993-04-01), Fritzberg et al.
patent: 5204357 (1993-04-01), Henning et al.
Bryson et al., Inorg. Chem. vol. 29, "Protecting Group in the Preparation of Thiolate Complexes of technetium", pp. 2948-2951 (1990).
Kung, Nucl. Med. Biol., vol. 17, No. 1, "Radiopharmaceuticals for CNS Receptor Imaging with SPECT", pp. 85-92 (1990).

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