Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1987-11-03

1990-03-13

Yarbrough, Amelia Burgess

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549369, A61K 31075

Patent

active

049083805

ABSTRACT:
The invention concerns novel pharmaceutical compositions containing a 4(Z)-6-(2,4-diphenyl-1,3-dioxan-5-yl)-alkenoic acid which antagonizes one or more of the actions of thromboxane A.sub.2, together with a compound which inhibits the synthesis of thromboxane A.sub.2. The compositios are useful as medicines in treating a variety of diseases or medical conditions in which thromboxane A.sub.2 and/or other prostanoid contractile substances are involved.

REFERENCES:
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J. Med. Chem., 1986, 29, 1461-1468; Johnson et al.
J. Med. Chem., 1986, 29, 342-346; Cross et al.
Br. J. Pharmac., 1985, 86, 497-504, Ambler et al.
J. Med. Chem., 1985, 28, 164-170, Ford et al.
J. Med. Chem., 1981, 24, 1139-1148, Iizuka et al.
Journal of Medicinal Chemistry, 1981, vol. 24, No. 10; 1149-1155; Tanouchi et al.
J. Med. Chem., 1985, 28, 287-294; Kato et al.
J. Med. Chem., 1986, 29, 523-530, Wright et al.
Antihypertensive Drugs, (4410-4415).
Arzneim.-Forsch/Drug Res., 36(I), No. 1, (1986), Sincholle et al.
J. Med. Chem., 1987, 30, 1812-1818; Manley et al.
Thromb Haemostas, (Stuttgart), 52 (3), 364, (1984).

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