Inhibition of immune clearance using progesterone analogues

Details Inhibition of immune clearance using progesterone analogues Inhibition of immune clearance using progesterone analogues

1988-02-24

1990-03-13

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514885, A61K 3156

Patent

active

049083589

ABSTRACT:
Methods of modulating the clearance of antibody-coated cells from the circulation of mammals are disclosed. A compound having the formula ##STR1## wherein R and R.sub.1 individually are hydrogen or taken together form a double bond;

REFERENCES:
patent: 2648662 (1949-08-01), Julian et al.
patent: 3463852 (1969-08-01), Reiman et al.
patent: 4701450 (1987-10-01), Kelder et al.
Jungers et al., Hormonal Modulation in Systemic Lupus Erythematosus; Arthritis and Rheumatism 28: 1243-1249 (1985).
Friedman et al., Effect of Estradiol and Steroids on the Clearance of Immunoglobulin G-Coated Erythrocytes; J. Clin. Invest. 75: 162-167 (1985).
Nettl et al., The Effect of Endogenous and Synthetic Steroids on the Clearance of IgG and/or C3 Coated Cells; Blood Abs #264 (1984 suppl).
Shear et al., Clearance of Sensitized Erthrocytes in NZB/NZW Mice Effects of Castration and Sex Hormone Treatment; Eur. J. Immunol. 11:776 (1981).
Bach, J. F.; John Wiley & Sons (NY); "Immunology", p. 812 (1982), AHN et al; Danzol for the Treatment of Idiopathic Thrombocytopenic Purpura, N. Eng. J. Med., p. 1396 (1983).
Roubinian et al.; Androgenic Hormones Modulate Antibody Responses and Improve Survival in Murine Lupus; J. Clin. Inquist. 59:1066 (1977).
Siitri et al.; Sex Steroids and the Immune System, J. Steroid Biochem. 12:425-432 (1980).
Duncan et al.; An In Vivo Study of the Action of Antiglucocorticoids on Thymus Weight Ratio . . . J. Steroid Biochemistry 10:245-259 (1979).
Schreiber et al., "Effect of Danazol in Immune Thrombocytopenic Purpura", N. Engl. J. Med. 316: 503-508 (02/26/87).
Dougados et al., Arthritis Rheum. (Suppl) 28: 246 (1985).
Fretwell et al., J. Allergy Clin. Immunol 69: 306-310 (1982).
Terenius, "Affinities of Progestogen and Estrogen Receptors in Rabbit Uterus for Synthetic Progestogens", Steroids 23(6): 909-919 (1974).
DiSorbo et al., "Glucocorticoid Activity of Various Progesterone Analogs: Correlation Between Specific Binding Thymus and Liver and Biologic Activity", Ann N.Y. Acad. of Sci. 206: 355-368 (1977).
Schreiber et al., J. Clin Invest. 51: 575 (1972).
Atkinson et al., "Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes", J. Clin. Invest. 52(6): 1509-1517 (1973).
Schreiber et al., "Role of Antibody and Complement in the Immune Clearance and Destruction of Erythrocytes", J. Clin. Invest. 51: 583-589 (1972).
Sanders et al., "Hormonal Modulation of Modulation Clearance of IgG Sensitized Cells", Association of American Physicians (Abstract).

Affiliated with

Also associated with

Rating

Inhibition of immune clearance using progesterone analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of immune clearance using progesterone analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of immune clearance using progesterone analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-51315