Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1983-08-25
1985-08-06
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 534 10, A61K 4300, A61K 4900, C07F 722
Patent
active
045335419
ABSTRACT:
The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.
REFERENCES:
Yano et al., Int. J. Appl. Rad. Isot., 24: 319-325 (1973).
Srivastava et al., from Nuclear Medicine and Biology Advances, Ed., C. Raynaud, vol. 2, Pergamon Press, 1983, pp. 1635-1638.
Moretti et al., from Nuclear Medicine and Biology Advances, vol. 2, Ed., C. Raynaud, Pergamon Press, 1983, pp. 1651-1654.
Woo et al., from Radio Pharmaceuticals II, Soc. of Nucl. Med. 1979, pp. 147-154.
Oster et al., from Nuclear Medicine and Biology Advances, vol. 4, Ed., Rayaoud, 1983, pp. 3251-3256.
Meinken George E.
Richards Powell
Srivastava Suresh C.
Bogosian Margaret C.
Hightower Judson R.
Nucker Christine M.
The United States of America as represented by the United States
Weinberger James W.
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