Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-24
1994-04-05
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546133, C07D45302, A61K 3144
Patent
active
053005120
ABSTRACT:
This invention relates to compounds useful in treating 5-HT.sub.4 and/or 5-HT.sub.3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkoxy, halogen, amino, monoalkylamino, dialkylamino, acylamino and alkylsulfonylamino; R.sub.3 is selected from the group consisting of H, alkyl and cycloalkyl; X is NH or O; and Z is selected from the group consisting of ##STR2## pharmaceutical compositions including the compounds and a method for treating serotonin mediated conditions with the compositions which act as 5-HT.sub.4 agonists or antagonists and/or 5-HT.sub.3 antagonists.
REFERENCES:
Schiantarelli et al. Pharmacological Research 22, Supp. 2 453 Jan. 1990.
A. Dumuis et al. Azabicycloalkyl benzimidazolone derivatives as etc. Naunyn-Schmiedeberg; s Arch Pharmacol 343 245-251 Jan. 1991.
M. Turconi et al. Synthesis of a New Class of etc. J. Med. Chem. 33, No. 8 2101-2108 Jan. 1990.
U.S. Ser. No. 903,835 Jun. 24, 1992 D. L. Flynn et al.
Flynn Daniel L.
Moormann Alan E.
G. D. Searle & Co.
Kovacevic Cynthia S.
Rotman Alan L.
Spivack Phyllis G.
Williams Roger A.
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