Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-08-18
1998-03-31
Chan, Christina
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 794, 436518, 536 235, 536 241, 536 2431, 514 12, 935 4, 935 78, G01N 3353, G01N 33543, C12Q 168, C07H 2104
Patent
active
057337284
ABSTRACT:
Methods are disclosed for detecting and treating heart failure which are based on the down-regulatory activity of the cytoplasmic RNA-binding polypeptide, AUF1 (A+U-rich element RNA-binding/degradation Factor) toward .beta.-adrenergic receptors. Methods are disclosed for detecting pharmacologicals that inhibit the down-regulatory activity of AUF1 polypeptide for .beta.-adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 gene.
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Brewer Gary
Port J. David
Chan Christina
Pepper Frederick W.
Rabin Evelyn
Regents of the University of Colorado
Wake Forest University
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