1,4-disubstituted piperazines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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Details

540468, A61K 31495, C07D41306

Patent

active

060049618

ABSTRACT:
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

REFERENCES:
patent: 4208410 (1980-06-01), Rozsa et al.
patent: 5753678 (1998-05-01), Hohlweg et al.
Sindelar et al., Collection Czech. Chem. Commun., vol. 59, pp. 667-674, (1994).

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