Method for incorporating into a DNA or RNA oligonucleotide using

Details Method for incorporating into a DNA or RNA oligonucleotide using Method for incorporating into a DNA or RNA oligonucleotide using

1990-10-09

1995-07-11

Walsh, Stephen G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2533, 435 911, 435 9151, 435 941, C07H 2300, C12P 1934

Patent

active

054322723

ABSTRACT:
The disclosure describes a method for incorporating into double stranded DNA and RNA base pairs composed of pairing units that fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but with a pattern of hydrogen bonds holding the base pair together different from that found in the AT and GC base pairs (a "non-standard base pair").

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