HP530 compounds and process for preparing the same

Details HP530 compounds and process for preparing the same HP530 compounds and process for preparing the same

1991-03-12

1992-12-01

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549384, A61K 3135, C07D31178

Patent

active

051681005

ABSTRACT:
Disclosed are novel HP530 compounds, their derivatives or their pharmaceutically permissible salts, a process for preparing them and an antitumor substances containing them as active ingredient. The HP530 compounds and their derivatives expressed by the general formula below can be prepared by cultivating Streptomyces sp. HP530 (FERM BP-2786) or and chemically derivation. ##STR1## where X is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom, Y is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom and Z is a group expressed by the formula (II), (III) or (IV). ##STR2##

REFERENCES:
patent: 4954641 (1990-09-01), Sato et al.
The Journal of Antibiotics, vol. 42, No. 1, 149-153, (1989), "Ankinomycin, a Potent Antitumor Antibiotic".
The Journal of Antibiotics, vol. 42, No. 10, 1518-1519, (1989), "Antitumor Activity of Ankinomycin".

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