Nucleic acid encoding TGF-.beta. its uses

Details Nucleic acid encoding TGF-.beta. its uses Nucleic acid encoding TGF-.beta. its uses

1989-08-04

1992-12-01

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4351723, 4352402, 4353201, 530 27, 935 11, C12P 2102, C12N 1511

Patent

active

051680513

ABSTRACT:
Nucleic acid encoding TGF-.beta. has been isolated and cloned into vectors which are replicated in bacteria and expressed in eukaryotic cells. TGF-.beta. is recovered from transformed cultures for use in known therapeutic modalities. Nucleic acid encoding TGF-.beta. is useful in diagnosis and identification of TGF-.beta. clones.

REFERENCES:
patent: 4886747 (1989-12-01), Derynck et al.
Ullrich et al., EMBO J., 3(2):361-364 (1984).
Massague & Like, J. Biol. Chem., 260(5):2636-2645 (1985).
Seeburg et al., Nature 270: 486 (1977).
D'Andrea et al.; Nucleic Acids Res. 9: 3119 (1981).

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