Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-07-12
1994-08-23
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546273, 546147, 546176, 546146, 546256, 548495, 514307, 514314, 514333, 514419, G07D40110, A61K 3144
Patent
active
053408250
ABSTRACT:
Novel pro-drugs ##STR1## the variables are as defined in the specification. New and unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the dipeptoids are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment or with use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The pro-drugs are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the pro-drugs as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject pro-drug compounds in diagnostic compositions.
REFERENCES:
patent: 4164571 (1979-08-01), Bonfils et al.
patent: 4757151 (1988-07-01), Horwell
patent: 4997950 (1991-03-01), Murphy et al.
Wade Jr. Organic Chem. 1987, p. 349.
D. Horwell, et al., Eur. J. Med. Chem., (1990) 25, 53-60.
D. Horwell, et al., J. Med. Chem., 1991, 34, 404-414.
Chemical Abstracts, vol. 109, 1988, p. 666, 109:6970g.
Chemical Abstracts, vol. 113, 1990, p. 715, 113:132771p.
Horwell David C.
Pritchard Martyn C.
Richardson Reginald S.
Anderson Elizabeth M.
Fan Jane T.
Warner-Lambert & Company
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