Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

1993-01-07

1994-08-23

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514210, 514212, 5142358, 514252, 514253, 540598, 544121, 544230, 544238, 544295, 544357, 544359, 544360, 544368, 544372, 544373, 544377, 544392, 544393, A61K 31495, C07D23700, C07D29500, C07D40100

Patent

active

053408128

ABSTRACT:
Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R.sup.1 is an aryl or nitrogen containing heteroaryl radical, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is aryl, C.sub.4-8 alkyl or aryl(lower)alkyl, and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT.sub.1A antagonists and can be used, inter alia, for the treatment of CNS disorders, such as anxiety.

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Accia, et al. J. Chromatography, 1982 pp. 510-513 Jakobiec et al. Pol. J. Pharm. 1985 37 73-77.

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