Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-10-18
1991-03-05
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548371, 548372, A61K 31415, C07D23116
Patent
active
049978446
ABSTRACT:
The invention provides a series of novel heterocyclic amides of the formula I in which the group A CRa can be --CRb.dbd.CRa--, --CHRb--CHRa-- or --N.dbd.CRa--, the amidic group Re.L can be Re.X.CO.NH, Re.X.CS.NH or Re.NH.CO attached at position 4, 5 or 6 of the benzenoid moiety, Z is an acid group selected from the group consisting of carboxy, an acylsulphonamide residue of the formula CO.NH.SO.sub.n Rg and a tetrazolyl residue of the formula II, and the radicals Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, n, X, G.sup.1, Q and G.sup.2 have the meanings defined in the following specification.
The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
REFERENCES:
patent: 3271416 (1966-09-01), Shen et al.
patent: 3415841 (1968-12-01), Nordmann et al.
patent: 4277489 (1981-07-01), Vadoni
patent: 4499299 (1985-02-01), Bernstein et al.
Marx, J. L., Science, 1982, 215, 1380-1383.
Krell, R. D., J. Pharmacol. Exp. Ther., 1979, 211, 436.
Hannig, E., Kollmorgen, Chr. and Dressel, M., "Zur Kenntnis einiger Derivate des 1-Benzyl-6-aminoindazols", Pharmazie 29, H. 10-11 (1974), pp. 685-686.
Fleisch, Jerome H., Rinkema, Lynn E., Haisch, Klaus D., Swanson-Bean, Dorothy, Goodson, Theodore, Ho, Peter P. K., and Marshall, Winston S., "LY171883, 1-<2-Hydroxy-3-Propyl-4-<4-(1H-Tetrazol-5-yl) Butoxy>Phenyl>Ethanone, and Orally Active Leukotriene D.sub.4 Antagonist.sup.1 ", The Journal of Pharmacology and Experimental Therapeutics, vol. 233, No. 1, pp. 148-157 (1985).
J. A. Cook, et al., Pharm. Exp. Ther. (1985), 235, 470.
Bernstein Peter R.
Brown Frederick J.
Yee Ying K.
ICI Americas Inc.
Jackson Thomas E.
Miano Rosemary M.
Ramsuer Robert W.
LandOfFree
Indazole compounds, pharmaceutical compositions and use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indazole compounds, pharmaceutical compositions and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indazole compounds, pharmaceutical compositions and use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-497093