Method for augmenting fetal hemoglobin by treatment with activin

Details Method for augmenting fetal hemoglobin by treatment with activin Method for augmenting fetal hemoglobin by treatment with activin

1988-11-01

1991-03-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 435 725, 435 29, 435184, A61K 3738, A61K 3743

Patent

active

049978152

ABSTRACT:
A method is provided for inhibiting the .gamma.-globin to .beta.-globin switching in subjects afflicted with .beta.-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell disease or .beta.-thalassemias by periodically introducing into the subject prio r to natural completion of the switching process activin, inhibin, an inhibin chain or mixtures thereof.

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