Heterogeneous interpenetrating polymer networks for the controll

Details Heterogeneous interpenetrating polymer networks for the controll Heterogeneous interpenetrating polymer networks for the controll

1988-06-14

1990-06-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424 78, 424 81, 424485, 424486, 424487, 424488, A61K 914

Patent

active

049312871

ABSTRACT:
A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.

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