Polymer reversal on solid surfaces

Details Polymer reversal on solid surfaces Polymer reversal on solid surfaces

Filed on

1991-11-22

Date issued

1993-09-07

Examiner

Nutter, Nathan M.

Patent Class

Synthetic resins or natural rubbers -- part of the class 520 ser

SubClass

Synthetic resins

SubSubClass

Mixing of two or more solid polymers; mixing of solid...

Other Related Categories

530333, 530334, 530335, 530336, 530337, C08F28300, C08G 6348, C08G 6391

Type

Patent

Status

active

Patent number

052429741

Description

ABSTRACT:
A method for cyclization and reversal of the polarity of polymers on a substrate. The method provides for the formation of a polymer on a substrate (2) with a tether molecule (4). Through unmasking of a protective group (PG.sub.2) a cyclic polymer (6) is formed. Through cleavage of an appropriate bond, a polarity reversed polymer (8) is formed. The method finds particular application in the formation of, for example, peptides and oligonucleotides.

REFERENCES:
patent: 4722906 (1988-02-01), Guire
patent: 5004781 (1991-04-01), Rink
patent: 5064907 (1991-11-01), Bronstert et al.
patent: 5066716 (1991-11-01), Robey et al.
patent: 5143854 (1992-09-01), Pirrung et al.
Fodor et al., Science (1991) 251:767-773.
Geysen et al., J. Imm. Meth. (1987) 102:259-274.
Bodanszky, Principles of Peptide Synthesis, springer-Verlag, 1984, pp. 208-229.
Rovero et al., Tetrahedron Letters (1991) 32:2639-2642.
McMurray, Tetrahedron Letters (1991) 32:7679-7682.

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