Prodrugs for oxadiazole muscarinic agonists

Details Prodrugs for oxadiazole muscarinic agonists Prodrugs for oxadiazole muscarinic agonists

1988-07-18

1993-09-07

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514304, 514305, 514340, 514364, 546112, 546125, 546133, 546137, 546277, 548133, A61K 3144, C07D41304

Patent

active

052429270

ABSTRACT:
A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring and on the other ring carbon atom with a substituent which is convertible in vivo to an amino group, are potent muscarinic agonists, and exhibit improved CNS penetrability and duration of action compared with the corresponding amino compounds. The compounds are therefore useful in the treatment of neurological and mental illnesses.

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M. Bock et al., J. Med. Chem. 29, 1540 (1986).
B. Ringdahl, et al., J. Med. Chem. 31, 160-164 (1988).
Higuchi, T., et al., Prodrugs as Novel Drug Delivery Systems, Acs, Wa., 1975, p. 15.

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