Manufacture of tetramisole

Details Manufacture of tetramisole Manufacture of tetramisole

1975-08-01

1978-01-24

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D51304

Patent

active

040703630

ABSTRACT:
Process for the manufacture of 2-imino-3-(2-chloro-2-phenylethyl)thiazolidine (known intermediate in manufacture of the anthelmintic agent tetramisole) by reacting 2-imino-3-(2-hydroxy-2-phenylethyl)thiazolidine with chlorosulphonic acid and either aqueous hydrochloric acid or water. Preferred procedure involves use of chlorosulphonic acid and concentrated hydrochloric acid.

REFERENCES:
patent: 3478047 (1969-11-01), Doyle et al.
patent: 3642809 (1972-02-01), Bullock
patent: 3804847 (1974-04-01), Blakeney et al.
Morrison et al. "Organic Chemistry," pp. 529-530 (1966).
Wagner et al., "Synthetic Organic Chemistry" N.Y., Wiley and Sons, 1953 pp. 89-91.
Guyot et al. "Chemical Abstracts" 1920, vol. 14 p. 1658.
Theilheimer, "Synthetic Methods", 1968, p. 273, set 590.

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