Pharmaceutical compositions for the treatment of psoriasis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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A61K 3702

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active

052429059

ABSTRACT:
The invention comprises compositions and methods for the treatment of psoriasis. The compositions comprise compounds of the formula: ##STR1##

REFERENCES:
patent: 3458304 (1969-07-01), Hageman et al.
patent: 3950392 (1976-04-01), D'Alelio
A. Lahti et al., Contact Dermatitis, 12, 139-140 (1985).
A. Lahti et al., "Pharmaceutical Studies on Nonimmunologic Contact Urticaria In Guinea Pigs", Arch. Dermatol. Res., 299, 44-49 (1986).
W. Raab, H&G Nr. 10 (1984).
Lahty et al., Contact Dermatitis 3, 139-140 (1985).
Schafer G., Fumarsauretherapie der Psoriasis, Arztliche Praxis 30, 61, 1757-58 (1978).
Selecta 15, 1260-61 (1984).
Thaler et al., J. Invest. Dermatol. 75, 156-158 (1980).
Steinert et al., Biochemistry of Normal and Abnormal Differentiation, eds. I. A. Bereinstein and M. Seiji, Tokyo University Press, pp. 391-406 (1980).
J. Marach, Advanced Organic Chemistry, 3d ed., p. 339, J. Wiley and Sons, New York (1985).
Lochmueller, C. H. et al., Direct gas chromatographic resolution of enantiomers on optically active mesophases. IV. Effect of structure on selectivity and liquid crystalline behavior, J. Chromat. 178, 411-417 (1979).
Meek, J. L., Derivatizing reagents for high-performance liquid chromatography detection of peptides at the picomole level, J. Chromat. 266, 401-408 (1983).
Augustin, M., N-Maleyl amino acids and peptides, Z. Chem. 25, 18-19 (1985).
Portoghese, P. S. et al., Synthesis and opioid antagonist potencies of Naltrexamine Bivalent Ligands with Conformationally Restricted Spacers, J. Med. Chem. 29, 1650-1653 (1986).
Schellenberger, V. et al., A spectrophotometric assay for the characterization of the S' subsite specificity of .alpha.-chymotrypsin, Bioch. et Bioph. Acta 869, 54-60 (1986).
Nieboer C. et al., Systemic therapy with fumaric acid derivatives: New possibility in the treatment of psoriasis, J. Am. Acad. Derm. 20, 601-607 (1989).
Chemical Abstract No. 83-114855b.

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