Tetrapeptides and methods for their production

Details Tetrapeptides and methods for their production Tetrapeptides and methods for their production

1976-03-01

1977-07-12

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424177, 260 8, C07C10352

Patent

active

040353486

ABSTRACT:
New tetrapeptides having the formula A-R.sub.1 -Tyr(benzyl)-Ser(benzyl)-D-Ala-R.sub.2 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R.sub.1 is L-His(benzyl), D-Pro, or L-Trp; Tyr(benzyl) is D-Tyr-(benzyl) or L-Tyr(benzyl); Ser(benzyl) is D-ser(benzyl) or L-Ser(benzyl) and R.sub.2 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

REFERENCES:
patent: 3725380 (1973-04-01), Konig et al.
J. M. Stewart and J. D. Young, "Solid Phase Peptide Synthesis", Freeman and Co., San Francisco, 1969, pp. 9-13.
J. D. Roberts and M. C. Caserio, "Basic Principles of Organic Chemistry", Benjamin, Inc., N.Y., 1965, pp. 531, 563-564.
E. Schroder and K. Lubke, "The Peptides", vol. 1, Academic Press, N.Y., 1965, pp. 79-80.

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