Method for the preparation of 4'-(substituted)-amino-2-(substitu

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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584345, 584365, 584412, C07C 9710

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active

049067818

ABSTRACT:
A method for the preparation of 4'-(substituted)-amino-2-(substituted)amino-3',5'-dichloroacetophenone and salts thereof. The method involves the chlorination of the corresponding 4'-(substituted)amino-2-(substituted) aminoacetophenone and acid addition salts thereof in the presence of an anhydrous or aqueous solvent selected from ethyl alcohol, t-butyl alcohol and acetic acid. The invention describes the preparation of 4'-amino-2-(t-butylamino)-3',5'-dichloroacetophenone and the hydrochloride thereof.

REFERENCES:
patent: 2675409 (1954-04-01), Orloff et al.
patent: 3536712 (1970-10-01), Keck et al.

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