Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-o

Details Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-o Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-o

1989-06-30

1990-03-06

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 72, 544126, C07D45300

Patent

active

049067559

ABSTRACT:
The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(3H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.

REFERENCES:
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P. G. Sammes, et al., Journal of the Chemical Society, Chemical Communications, 1, 367-368 (1976).
B. Maurer, et al., Helvetica Chemica Acta, 59, 1169-1185 (1976).
P. Fludzinski, et al., J. Med. Chem., 30(9), 1535-1537 (1987).

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